When everyone else is writing songs about their love for GMail, I am reverting to old school mutt. It is simply the fastest way to read and manage large amounts of mail (The Rails mailing list comes to mind).
However, the default install did not work out for me, it mishandled international characters and formatting which made it unusable. After trying a bunch of options it finally came down to this:
port install mutt-devel -ncurses -pop -imap
Now, of course pop and imap had nothing to do with it, but I am using the most excellent offlineimap so I do not need them.